PolyGR‐containing aggregates link with AD pathological hallmarks and autophagy pathway
Our data demonstrates that polyGR+ aggregates are an important proteinopathological feature in AD autopsy brains. Additionally, our data suggests that co-localization of autophagy and proteasome markers p62 and LC3B with polyGR+ aggregates could lead to dysregulation of autophagy-lysosomal pathway, which contributes to disease pathogenesis.
Authors
- J. C. Troncoso
- Shu Guo (ORCID: https://orcid.org/0000-0001-9094-1602)
- Stefanie Ng
- Alexandra Melloni (ORCID: https://orcid.org/0000-0002-0657-5919)
- Ana María Piddo Mijares
- Logan Bell (ORCID: https://orcid.org/0009-0005-9403-888X)
- Huong T. Phuong
- Svitlana Yegorova
- Bradley T. Hyman
- Jennifer L. Phillips
- Olga Pletnikova
- Rodrigo Francisco Tomas
- Lien Nguyen
- Stefan Prokop
- Cemal Akamese
- Laura P. W. Ranum
- H. Brent Clark
Institutions
- University of Minnesota (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101865
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00