Accuracy of cerebrospinal fluid biomarker ratios to determine amyloid positron‐emission tomography status: a diagnostic test accuracy meta‐analysis

All three CSF biomarker ratios (Aβ42/Aβ40, pTau/Aβ42, and tTau/Aβ42) analyzed were highly concordant with amyloid PET. However, the pTau/Aβ42 ratio consistently showed higher concordance with amyloid PET positivity than the Aβ42/Aβ40 or tTau/Aβ42 ratio across multiple analysis methods, suggesting that pTau/Aβ42 may be the preferred CSF biomarker ratio for confirmation of the diagnosis of AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_100941
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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article

Accuracy of cerebrospinal fluid biomarker ratios to determine amyloid positron‐emission tomography status: a diagnostic test accuracy meta‐analysis

Eino Solje, Julian G Martins, Sraboni Sarkar, Pablo Martínez‐Lage
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Accuracy of cerebrospinal fluid biomarker ratios to determine amyloid positron‐emission tomography status: a diagnostic test accuracy meta‐analysis

Eino Solje, Julian G Martins, Sraboni Sarkar, Pablo Martínez‐Lage
article en

Abstract

All three CSF biomarker ratios (Aβ42/Aβ40, pTau/Aβ42, and tTau/Aβ42) analyzed were highly concordant with amyloid PET. However, the pTau/Aβ42 ratio consistently showed higher concordance with amyloid PET positivity than the Aβ42/Aβ40 or tTau/Aβ42 ratio across multiple analysis methods, suggesting that pTau/Aβ42 may be the preferred CSF biomarker ratio for confirmation of the diagnosis of AD.

Alzheimer s & DementiaVol. 21(S2)
Springer Nature (Germany) (DE), University of Eastern Finland (FI), Rotary International (US), Kuopio University Hospital (FI), Eastern Finland Laboratory Center (FI), Fundacion CITA Alzheimer (ES)
Partnerships for the goals
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Accuracy of cerebrospinal fluid biomarker ratios to determine amyloid positron‐emission tomography status: a diagnostic test accuracy meta‐analysis — Eino Solje, Julian G Martins, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS