Identification of genetic modifiers influencing disease risk in autosomal dominant Alzheimer disease mutation carriers
We identified 4 genetic modifiers that influence disease risk and affect multiple ADAD mutations, offering insights for future clinical trials and genetic counseling.
Authors
- Cyril P. Pottier (ORCID: https://orcid.org/0000-0002-3049-9346)
- John Budde (ORCID: https://orcid.org/0000-0001-7778-7276)
- Natalie S. Ryan (ORCID: https://orcid.org/0000-0003-0361-7455)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Menghan Liu (ORCID: https://orcid.org/0009-0008-9902-5983)
- Laura Ibanez
- Dominantly Inherited Alzheimer Network (DIAN)
- Matthew Johnson
- Randall J. Bateman
- Maulikkumar P Patel
- Alison M. Goate
- David M. Holtzman
- Arda Cetin
- Alan E. Renton
- John C. Morris
- Carlos Cruchaga
Institutions
- Washington University in St. Louis (US)
- Hope Center for Neurological Disorders (US)
- UK Dementia Research Institute (GB)
- Prevent Alzheimer’s Disease 2020 (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105550
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00