Harnessing Pcasl : Unveiling Cerebral Hemodynamics And Advancing Biomarkers In Alzheimer's Disease ‐ A Simultaneous MR/PET Study

The study signifies the potential of pCASL in the diagnosis of AD. It confirms the prevalentinvolvement of parietal and temporal lobes, demonstrating hypo-perfusion and hypo-metabolism, which isconsistent with previous studies indicating DMN disruption. Approximately 60-75% of patients exhibitedhypo-perfusion in the parietal lobes, supporting the role of pCASL as a reliable indicator of AD-relatedimpairments in visuospatial function and attention. Our research emphasizes the need for standardizedpCASL protocols to enable consistent and comparable results across studies. The integration of pCASL withother imaging modalities and biomarkers could provide a comprehensive understanding of ADpathophysiology. This multimodal approach, coupled with larger and more diverse study populations, maypave the way for the identification of robust CBF-based biomarkers, enhancing early diagnosis.