Multi‐assay characterization of human iPSC derived microglia‐like cells in response to recombinant antibodies and immunogenic stimuli
The IBRI 104.G iPSC line readily differentiates into highly ramified microglia-like cells that exhibit many properties of human microglia. iMG may serve as a valuable model system for examining tool molecules in vitro which seek to modulate neuroinflammation by targeting brain myeloid cells.
Authors
- Jacob Smiley
- Alison Haskell
- Rabea Hinkel (ORCID: https://orcid.org/0000-0002-2936-0400)
- Joshua A. Kulas (ORCID: https://orcid.org/0000-0002-8055-1894)
- Mustapha Moussaif
- June Javens‐Wolfe
- Shaoyou Chu
- Timothy I. Richardson
- William Carter
- Abdul Syed
Institutions
- Indiana Biosciences Research Institute (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103179
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00