Engineering FRET biosensor of TDP‐43 to probe formation of TDP‐43 pathology in vitro
This study presents a novel FRET-based biosensor for tracking TDP-43 aggregation in living neurons. Our approach enables real-time monitoring of TDP-43 pathology and facilitates the identification of molecular pathways disrupted by its accumulation.
Authors
- Shichen Wu
- Han Zhao
- Junkai Xie (ORCID: https://orcid.org/0009-0001-8758-3741)
- Haowei Xu (ORCID: https://orcid.org/0009-0001-3780-8682)
- Chongli Yuan
Institutions
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107363
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00