Plasma‐based proteomic analysis identifies distinct molecular subtypes of Alzheimer's disease pathogenesis
This study identifies protein signatures associated with amyloid β and tau pathology in real-world clinical cohorts, highlighting LRRN1 as both a promising candidate diagnostic biomarker and potential therapeutic target for specific AD subtypes.
Authors
- He Zhao (ORCID: https://orcid.org/0000-0002-8264-9297)
- Liu Shi (ORCID: https://orcid.org/0000-0003-1752-0419)
- Alejo Nevado‐Holgado (ORCID: https://orcid.org/0000-0001-9276-2720)
- Rashmi Maurya (ORCID: https://orcid.org/0000-0001-8496-017X)
- Laura M Winchester
- EMIF‐AD Consortia
- Shisong Jiang
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106114
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00