Younger age of onset and atypical clinical syndrome are associated with greater locus coeruleus degeneration in Alzheimer's disease
The locus coeruleus, especially the rostral and middle levels, are especially vulnerable in young-onset and atypical forms of AD. The loss of noradrenergic neuromodulation may contribute to the atypical symptomatology.
Authors
- Sara Dunlop
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Billie J. Matchett (ORCID: https://orcid.org/0000-0002-5941-7367)
- Fadi S. Hanna Al‐Shaikh (ORCID: https://orcid.org/0000-0002-4015-013X)
- Darren M. Rothberg
- Melissa E. Murray
- Idaly Velez‐Uribe
- Josalen Ventura
- Neill R. Graff‐Radford
- Alexander Mannsbart
- Ranjan Duara
Institutions
- University of California, San Francisco (US)
- Jacksonville College (US)
- WinnMed (US)
- University Memory and Aging Center (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103303
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00