Correlation between cerebral small vessel disease biomarkers and plasma GFAP in participants of the encephalopathy and memory clinic cohort, in Thailand: A Story from a Middle‐Income Country
The total CSVD score and plasma GFAP showed a stronger positive correlation in the non-AD group than in the AD group. After adjusting for p-tau 217, an AD biomarker, the correlation between total CSVD score and plasma GFAP became stronger. These findings suggest that plasma GFAP alone may have limitations in assessing CSVD burden in AD due to shared mechanisms and biomarkers. Further validation of other potential VCID fluid biomarkers is warranted.
Authors
- Prawit Oangkhana (ORCID: https://orcid.org/0000-0002-7644-4236)
- Watayuth Luechaipanit
- Thachamai Smitasiri (ORCID: https://orcid.org/0009-0000-7306-7271)
- Thanakit Pongpitakmetha (ORCID: https://orcid.org/0000-0002-8338-4649)
- Kittithatch Booncharoen
- Yuttachai Likitjaroen (ORCID: https://orcid.org/0009-0009-7488-325X)
- Jedsada Khieukhajee (ORCID: https://orcid.org/0009-0007-8867-8420)
- Adipa Chongsuksantikul
- Tatchaporn Ongphichetmetha (ORCID: https://orcid.org/0000-0002-9063-2575)
- Sekh Thanprasertsuk (ORCID: https://orcid.org/0000-0002-0267-1372)
- Poosanu Thanapornsangsuth (ORCID: https://orcid.org/0000-0002-1317-9404)
- Thanaporn Haethaisong
- Juthamas Rianaree
- Thanapoom Taweephol (ORCID: https://orcid.org/0009-0003-9447-2622)
- Nattanich Pornteparak
Institutions
- Thai Red Cross Society (TH)
- Siriraj Hospital (TH)
- Chulalongkorn University (TH)
- Mahidol University (TH)
- Bangkok Hospital (TH)
- King Chulalongkorn Memorial Hospital (TH)
- Phramongkutklao Hospital (TH)
- Ministry of Science and Technology Thailand (TH)
- Neurological Institute of Thailand (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098874
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00