A difference that matters: the aortic root anatomy of large animal models vs. humans
Validation of <i>ex vivo</i> silicone casting against <i>in vivo</i> CT confirmed its suitability for scalable anatomical assessment while aligning with animal welfare principles. These findings support refinement of animal selection strategies and provide an anatomically grounded framework for preclinical evaluation of transcatheter valve technologies.
Authors
- Peter Zilla (ORCID: https://orcid.org/0000-0001-9502-4109)
- Waled Hadasha
- Venessa Strauss
- P. Human
- Bruno Karl Podesser (ORCID: https://orcid.org/0000-0002-4641-7202)
- Y. Schneeberger
- Harish Appa
- Helga Bergmeister (ORCID: https://orcid.org/0000-0003-3269-0168)
- Ferdinand Vogt (ORCID: https://orcid.org/0000-0002-1924-6823)
- Q. M. S. H. Said-Hartley
- Jacques Scherman
- Lenard Conradi
Institutions
- University of Cape Town (ZA)
- Universität Hamburg (DE)
- Groote Schuur Hospital (ZA)
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsklinikum St. Pölten (AT)
- Paracelsus Medizinische Privatuniversität (DE)
- University Hospital Cologne (DE)
- Access Technologies (US)
- Artistic Realization Technologies (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.3389/fcvm.2025.1699721
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00