Multiomic Analysis of iPSC‐Derived Neural Spheroids Reveals Cell‐Type and Ancestry‐Specific Regulatory Landscapes of Alzheimer's Disease GWAS Genes
Our findings underscore the critical role of ancestry in shaping the regulatory landscapes of AD-related genes, particularly in astrocytes and neurons. By expanding our understanding of ancestry-specific GRA, this study provides crucial insights into the genetic mechanisms underlying AD risk and offers a foundation for more and innovative precision medicine approaches.
Authors
- Patrice Whitehead
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Wanying Xu (ORCID: https://orcid.org/0009-0000-3262-2013)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Sergio Tejada
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Lauren Coombs
- Maria C Robayo
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Mario Cornejo‐Olivas
- Luciana Bertholim Nasciben
- Goldie S Byrd
- Margaret Pericak‐Vance
- Larry D Adams
- Farid Rajabli
- Fulai Jin
- Sofia Moura
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104353
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00