Retinal Vascular Pathology in MCI and AD: Links to Cerebral Amyloid Angiopathy and Cognition
Retinal arteriolar Aβ accumulation, pericyte loss, and TJ dysfunction contribute to early AD vascular pathology. If validated in larger cohorts, these findings support retinal vascular biomarkers as tools for predicting cognitive decline, monitoring AD progression, and assessing CAA severity.
Authors
- Altan Rentsendorj (ORCID: https://orcid.org/0009-0001-4322-8107)
- Jonah Doustar (ORCID: https://orcid.org/0000-0002-3029-0067)
- Dieu‐Trang Fuchs
- Maya Koronyo‐Hamaoui (ORCID: https://orcid.org/0000-0003-2864-8442)
- Oana M. Dumitrascu (ORCID: https://orcid.org/0000-0003-2033-449X)
- L. S. Schneider
- Keith L Black
- Haoshen Shi
- Roxana O. O Carare
- Julie A Schneider
- Yosef Koronyo
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Rush University Medical Center (US)
- Mayo Clinic in Arizona (US)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100907
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00