Diabetes Influences the Fusion of AutophagosomesWith Lysosomes in SH‐SY5Y Cells and Induces Aβ Deposition and CognitiveDysfunction in STZinduced Diabetic Rats
Diabetes disrupts autophagosome-lysosome fusion, impairing Aβ clearance and lysosomal function, leading to increased apoptosis and cognitive dysfunction. These findings provide insights into the mechanisms of diabetes-related AD and suggest potential therapeutic targets.
Authors
- Qiumin Qu
- louyan Ma
Institutions
- Wuhan No.1 Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101510
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00