Genomic and epigenomic insights into purkinje and granule cells in Alzheimer's disease‐related dementia using single‐nucleus multiome analysis
This comprehensive cell subtype-specific regulatory landscape in the human cerebellum identified here offer novel genomic and epigenomic insights into the neuropathology and pathobiology of AD/ADRD and other neurological disorders if broadly applied.
Authors
- Borna Bonakdarpour (ORCID: https://orcid.org/0000-0003-0028-0535)
- YaYan Feng
- Margaret E Flanagan
- Feixiong Cheng
- Jeffrey L. Cummings
Institutions
- Northwestern University (US)
- Cleveland Clinic (US)
- University of Nevada, Las Vegas (US)
- The University of Texas at San Antonio Health Science Center (US)
- Lou Ruvo Brain Institute (US)
- Northwestern Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105855
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00