Oxygen Glucose Deprivation Differentially Potentiates Aβ40 <sub>E22Q</sub> ‐ and Aβ42‐induced Cerebral Endothelial Cell Death, Barrier Dysfunction, and Angiogenesis Impairment
This study reveals specific mechanisms through which hypoxia, low glucose and amyloidosis mutually operate to produce brain EC dysfunction and death, highlighting new potential molecular targets against vascular pathology in comorbid AD/CAA and hypoperfusion conditions.
Authors
- Silvia Fossati (ORCID: https://orcid.org/0000-0002-2047-222X)
- Ashley M Carey
Institutions
- Temple University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103561
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00