EMBOLISE randomized surgical trial for subdural hematoma: clinical benefits beyond reoperation with middle meningeal artery embolization
Among patients with symptomatic subacute/chronic SDH, reoperation was associated with increased rates of mRS worsening and higher mRS scores at follow-up. Adjunctive Onyx MMAe resulted in lower rates of hematoma recurrence/progression and fewer unscheduled physician follow-up visits. Thus, in addition to reducing surgical reoperation rates, adjunctive MMAe led to improved clinical outcomes and reduced healthcare encounters.
Authors
- Aniel Majjhoo
- Justin F. Fraser (ORCID: https://orcid.org/0000-0002-5980-3989)
- Christopher Roark (ORCID: https://orcid.org/0000-0003-3893-3511)
- Walter S. Lesley (ORCID: https://orcid.org/0000-0003-4612-4781)
- Marshall C. Cress (ORCID: https://orcid.org/0000-0001-7510-7775)
- Ricardó A. Hanel (ORCID: https://orcid.org/0000-0001-7195-5806)
- Joshua William Osbun (ORCID: https://orcid.org/0000-0003-4308-9669)
- Jonathan Andrew Grossberg (ORCID: https://orcid.org/0000-0002-1152-8826)
- J Santarelli
- Joe Bernard (ORCID: https://orcid.org/0000-0002-4270-4458)
- Robert E. Harbaugh (ORCID: https://orcid.org/0000-0003-3607-7926)
- Levy Elad
- Thomas W. Link (ORCID: https://orcid.org/0000-0003-1325-8847)
- Ramesh Grandhi (ORCID: https://orcid.org/0000-0001-9000-6083)
- Christopher P. Kellner (ORCID: https://orcid.org/0000-0003-4604-8205)
- Clemens Maria Schirmer (ORCID: https://orcid.org/0000-0003-1743-8781)
- A Khalessi
- Paul Mazaris
- Jason W. Tarpley (ORCID: https://orcid.org/0000-0003-1554-9592)
- Jesse Liu (ORCID: https://orcid.org/0000-0001-5819-7860)
- J Davies
- Walavan Sivakumar (ORCID: https://orcid.org/0000-0002-1367-2100)
- Joshua Billingsley
- Peng Roc Chen (ORCID: https://orcid.org/0000-0001-8438-132X)
- Patrick Youssef
- A Paul
- Kathleen Dlouhy
- Hakeem J Shakir (ORCID: https://orcid.org/0000-0003-4234-340X)
- Daniel H. Sahlein (ORCID: https://orcid.org/0000-0002-6591-9427)
- Neil V. Patel (ORCID: https://orcid.org/0000-0002-3396-5568)
- M Imran Chaudry
- Ameer E Hassan
- Bradley A. Gross
- Matthew J Koch
- Michael R Levitt
- Mark Bain
- Maxim Mokin
- Jared Knopman
- Jesse Jones
- Jens Fiehler
- Mouhammad Jumaa
- Thomas Wolfe
- Adnan H Siddiqui
- R Webster Crowley
- William J Mack
Institutions
- Gates (United States) (US)
- Aurora Health Care (US)
- University of Toledo Medical Center (US)
- Prisma Health (US)
- Lahey Hospital and Medical Center (US)
- McLaren Regional Medical Center (US)
- University of Denver (US)
- Cleveland Clinic (US)
- Westchester Medical Center (US)
- University of Kentucky (US)
- Orlando Health (US)
- Emory University (US)
- Universität Hamburg (DE)
- Oregon Health & Science University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- University of Utah (US)
- University of South Florida (US)
- Keck Hospital of USC (US)
- North Shore University Hospital (US)
- Orlando Regional Medical Center (US)
- Advocate Lutheran General Hospital (US)
- Tampa General Hospital (US)
- Carolinas Medical Center (US)
- ProMedica Toledo Hospital (US)
- University of Iowa Hospitals and Clinics (US)
- The University of Texas Rio Grande Valley (US)
- The Ohio State University Wexner Medical Center (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- University of California San Diego (US)
- Carolina Neurosurgery and Spine Associates (US)
- Orthopaedic Associates of Michigan (US)
- Presbyterian Hospital (US)
- McLaren Macomb (US)
- UPMC Health System (US)
- Baylor Scott & White Medical Center - Temple (US)
- Lahey Medical Center (US)
- University Medical Center Hamburg-Eppendorf (DE)
- ProMedica Russell J. Ebeid Children's Hospital (US)
- Baptist Medical Center Jacksonville (US)
- Little Company of Mary Hospital (US)
- Pacific Heart Institute (US)
- University of Pittsburgh Medical Center (US)
- Memorial Hermann–Texas Medical Center (US)
- Neurological Surgery (US)
- The University of Texas Health Science Center (US)
- Baylor Scott & White Health (US)
- Campbell Collaboration (NO)
- Saint Louis University (US)
- University of Oklahoma Health Sciences Center (US)
- Rush University (US)
- Geisinger Health System (US)
- University at Buffalo, State University of New York (US)
- Geisinger Commonwealth School of Medicine (US)
- Albany Medical Center Hospital (US)
- Penn State Milton S. Hershey Medical Center (US)
- Michigan State University (US)
- The University of Texas Health Science Center at Houston (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of NeuroInterventional Surgery
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1136/jnis-2025-024587
- Primary Topic
- Neurosurgical Procedures and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00