Region‐specific increase in CK2 expression is associated with decreased 3R:4R tau ratio in AD patients

This data suggests that the previously identified positive correlation between CK2 and hyperphosphorylated tau in AD patients may be connected to the unique pathogenesis of a mixed-isoform tauopathy. Aberrant hippocampal CK2 expression may influence region-specific increases in 4R tau relative to 3R tau and drive other AD-specific aspects of pathology. These findings support future research involving the inhibition of CK2 as a potential therapeutic intervention in AD.