Genome‐Wide Analysis of Memory, Language, and Executive Function Reveals Domain‐Specific Genetic Architecture in Alzheimer Disease
These findings enhance our understanding of the biological mechanisms that contribute to domain-specific cognitive decline in AD, underscoring the distinct processes driving deficits in memory, language, and executive function. Such insights pave the way for more precise, syndrome-focused interventions, ultimately guiding a precision medicine approach tailored to the heterogeneous clinical manifestations of AD.
Authors
- Vanessa Aguiar‐Pulido
- Kyle M Scott
- Farid Rajabli
- Azra Emekci
Institutions
- Pioneer (United States) (US)
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105459
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00