Grabody B, an IGF1R‐targeting Molecular Shuttle, Sustains Brain Penetration of Therapeutic Antibody in Aged Mice by Multiple, Novel Transcytosis Pathways
We confirm that Grabody B improves brain penetration of therapeutics with avoidance of the BCSFB-related routes. Grabody B utilizes multiple transcytosis pathways including Clathrin, caveolin, and FEME, which enables sustained brain penetration in aged rodents.
Authors
- Hyesu Yun
- S. Lee
- Miran Yoo
- Do‐Geun Kim
- Seung‐Hwan Kwon (ORCID: https://orcid.org/0000-0001-7965-5875)
- Sungwon An (ORCID: https://orcid.org/0000-0001-8828-1908)
- Hakju Kwon
- Dongin Kim (ORCID: https://orcid.org/0000-0002-6578-2408)
- Sumin Hyeon
- Bruce Kim
- Dongwhan Kim
Institutions
- ABL Bio (South Korea) (KR)
- Korea Brain Research Institute (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103122
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00