Novel biallelic MEI1 variants cause female infertility characterized by multiple pronuclei formation and aberrant embryonic development
Our findings broaden the spectrum of MEI1 variants associated with embryonic developmental arrest and highlight the essential role of MEI1 in oocyte meiosis and early embryonic chromosomal stability.
Authors
- Xuedan Jiao
- Ping Yuan (ORCID: https://orcid.org/0000-0001-5557-7964)
- Yuqin Zhu (ORCID: https://orcid.org/0009-0001-7146-5310)
- Qingxue Zhang (ORCID: https://orcid.org/0000-0002-5173-1351)
- Hui Chen (ORCID: https://orcid.org/0000-0002-3180-5595)
- Li Zhou
- Yingying Xia
- Xiaoyu Zuo
- Wenyi Liu
- Yihua Liang
Institutions
- Sun Yat-sen University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Guangdong Province Stomatological Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Institut thématique Génétique, génomique et bioinformatique (FR)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s13048-025-01890-1
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China