Molecular Drivers of Regional and Cellular Vulnerability to Tau Pathology and Neurodegeneration
We conclude that excitatory neurons are most vulnerable to tau pathology across tauopathies and selective vulnerability to tau pathology could arise from changes in neurotransmission and synaptic compositions, potentially due to an altered Mef2c transcription network. This study provides important data on molecular drivers of regional and cellular susceptibility to neurodegeneration.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- M. Wang
- Li Shen (ORCID: https://orcid.org/0000-0002-5190-2851)
- Ana Carolina Pereira
- Saraswathi Subramaniyan
- V. Patel
- P. R. Hof
- Robert D. Blitzer (ORCID: https://orcid.org/0000-0001-8829-1532)
- Diede W. M. Broekaart (ORCID: https://orcid.org/0000-0002-4842-0659)
- Eric F. Schmidt
- Abhijeet Sharma
- Aarthi Ramakrishnan
- Bin Zhang
Institutions
- University of California, San Francisco (US)
- Rockefeller University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103209
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00