Autoimmune aspects of Alzheimer's disease as exemplified by the diversity of autoantibodies found in patient serum and CSF

Despite consistent identification of some autoantibodies in AD, their potential causal role in disease initiation and progression has not been experimentally demonstrated. We suggest follow-up confirmatory and validation studies with sufficient power, preferably by employing orthogonal testing techniques. Uncovering the putative autoimmune components of AD is important and could pave the way to new concepts for AD pathogenesis, diagnosis and therapy.