Role of microglia reactivity and sex on the cognitive decline linked to sporadic hypercholesterolemia
Taken together, our results demonstrate that sporadic hypercholesterolemia in mice was accompanied by deficits in hippocampal-dependent memory tasks and a reduction in microglial presence in the perivascular area. Notably, minocycline treatment improved memory in hypercholesterolemic mice and increased Claudin-5 immunocontent without altering microglial density or morphology or their presence in the perivascular area. No significant sex differences were observed, indicating that the effects of sporadic hypercholesterolemia in mice are consistent across sexes.
Authors
- David Engblom (ORCID: https://orcid.org/0000-0001-6501-9077)
- J. C. Fonseca Moreira
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Hémelin Resende Farias (ORCID: https://orcid.org/0000-0003-4918-4982)
- M. Irigaray Costa
- Tainá Schons (ORCID: https://orcid.org/0000-0001-8330-3485)
- Alessandra Gonçalves Machado (ORCID: https://orcid.org/0000-0002-6050-0985)
- Daniel Pens Gelain
- L. M. Santos
- Gabriela Joras Baumart
- Natália Baltazar Nascimento
- Alex Paulo Padilha
- Jade de Oliveira
- Andreza Fabro de Bem
- Rachel KSS Bast
Institutions
- Linköping University (SE)
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Brasília (BR)
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105776
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00