TOX‐AD: Exposome Effects of the Environmental Neurotoxicants Lead, Cadmium, and Arsenic on Brain Metal‐Metalloid Accumulation and Alzheimer's Disease Pathobiology
MODEL-AD mice exposed to Pb, Cd, or As accumulate metal/metalloid toxicants in blood and region-specific accumulation in brain. Moreover, these exposures revealed toxicant-specific alterations in gene expression and gene module profiles relevant to AD pathobiology.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Nicola Lupoli
- Olga Minaeva (ORCID: https://orcid.org/0000-0002-7911-6510)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Juliet A. Moncaster (ORCID: https://orcid.org/0000-0002-7849-4325)
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Leandro Ceotto Freitas Lima
- Lee E Goldstein
Institutions
- Boston University (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106786
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00