Age differences in spontaneous cerebrovascular reactivity at rest
Independently living and cognitively healthy older adults showed reduced whole brain and regional spontaneous CVR compared to younger adults. The observed age-group differences in spontaneous CVR at rest suggests that changes in cerebrovascular function may occur earlier in the lifespan and predate irreversible neuronal damage and cognitive decline. Further research is needed to determine if spontaneous CVR may be used as a valuable biomarker for age-related cognitive decline, and to determine the age range at which spontaneous CVR responses begin to decline.
Authors
- Daniel A. Nation (ORCID: https://orcid.org/0000-0002-9123-0658)
- Fatemah Shenasa (ORCID: https://orcid.org/0000-0001-9030-4857)
- Allison C Engstrom (ORCID: https://orcid.org/0000-0002-4676-0430)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Jillian L. Joyce (ORCID: https://orcid.org/0000-0001-5311-4798)
- Trevor Lohman (ORCID: https://orcid.org/0000-0002-9634-702X)
- John Paul M Alitin (ORCID: https://orcid.org/0009-0001-5494-9639)
- Arunima Kapoor (ORCID: https://orcid.org/0000-0003-4622-8951)
- Isabel J. Sible (ORCID: https://orcid.org/0000-0003-3922-0628)
- Aimée Gaubert (ORCID: https://orcid.org/0000-0001-6812-522X)
- Anisa Marshall (ORCID: https://orcid.org/0000-0001-5457-2520)
- Danny JJ Wang
Institutions
- University of Southern California (US)
- University of California, San Francisco (US)
- University of California, Irvine (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101198
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00