Electronic health records to test influence of race and multimorbidity on plasma biomarkers
In this real-world dataset, we identified effects of comorbidities (LDL-cholesterol, diabetes, liver, and kidney functioning) on plasma biomarkers. The p-tau217/Aβ42 ratio had low rates of undetermined, and it may help to account for effects of morbidities on plasma levels; still, creatinine remained a significant confound.
Authors
- Colleen Morse
- L. Shaw
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Rory Boyle (ORCID: https://orcid.org/0000-0003-0787-6892)
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- Katheryn A. Q. Cousins
- Marina Serper
- Anurag Verma
- Corey T. McMillan
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097254
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00