Association between retinal changes assessed by OCT and cerebral amyloid burden measured by PET imaging in Alzheimer's continuum: a systematic review

Overall, while the exact association between retinal changes and brain Aβ- status remains inconclusive, this review suggests that retinal changes revealed by OCT, especially GCL/IPL reduction, could be assistive in the early detection of AD and Aβ positivity. However, further studies employing standardized methodologies and well-defined participant subgroups are needed to validate its potential for clinical use.