Association of cumulative deficit frailty with brain age and Alzheimer’s disease-related brain structure starting in late-middle age
CDF was associated with age-related brain structure via strong time-invariant common variance as well as weaker across-time factors. By contrast, the association between CDF and AD-related brain structure was via moderate common variance and was not temporally dynamic. Together, this suggests that CDF is differentially associated with age-related and AD-related brain changes and may be a clinically relevant risk factor for pathological brain aging.
Authors
- Erik Buchholz
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- McKenna E. Williams (ORCID: https://orcid.org/0000-0002-4106-5025)
- Michael C. Neale (ORCID: https://orcid.org/0000-0003-4887-659X)
- Nathan A. Gillespie (ORCID: https://orcid.org/0000-0001-8655-2823)
- Donald J. Hagler (ORCID: https://orcid.org/0000-0002-0331-3294)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Rongxiang Tang (ORCID: https://orcid.org/0000-0003-0406-9024)
- Stephen M Dorros
- Anders M. Dale (ORCID: https://orcid.org/0000-0002-6126-2966)
- J R Hunt
- Chandra A Reynolds
- Matthew S. Panizzon
- Christine Fennema-Notestine
- for the Vietnam Era Twin Study of Aging
Institutions
- University of Arkansas at Little Rock (US)
- Virginia Commonwealth University (US)
- University of Colorado Boulder (US)
- University of Washington (US)
- Texas College (US)
- University of California San Diego (US)
- Texas A&M University (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1093/gerona/glaf283
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Temple University
- National Institutes of Health
- National Institute of Mental Health