The MRI signature of LATE‐NC‐associated hippocampal sclerosis extends beyond the medial temporal lobe
LATE-NC-associated hippocampal sclerosis is linked to an in-vivo atrophy pattern on MRI that extends well beyond the hippocampus and includes several temporo-limbic cortical areas known to accumulate TDP-43 pathology in LATE-NC. This signature could help to improve clinical detection of this pathologic condition in-vivo.
Authors
- Michel J. Grothe (ORCID: https://orcid.org/0000-0003-2600-9022)
- Pascual Sánchez‐Juan (ORCID: https://orcid.org/0000-0002-6081-8037)
- Linda Zhang (ORCID: https://orcid.org/0000-0003-2122-9771)
- Alberto Rábano
- Jesús Silva‐Rodríguez
- Francisco J. López‐González
Institutions
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098997
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00