Identification of candidate causal risk genes and pathways in Alzheimer's disease and Lewy body dementia
Functional mapping nominated dozens of AD and LBD candidate causal risk genes. Pathway enrichment implicated microglial lipid metabolism and endocytosis as well as oligodendroglial amyloid, lipid metabolism, and blood-brain barrier as pathophysiological mechanisms shared across AD and LBD. These analyses also suggested roles for mitochondria and synapses in LBD microglia and oligodendroglia, respectively, enhancing our understanding of LBD genetic risk mechanisms.
Authors
- Stella Dracheva (ORCID: https://orcid.org/0000-0001-5917-8688)
- Bryan J. Traynor (ORCID: https://orcid.org/0000-0003-0527-2446)
- Tulsi Patel (ORCID: https://orcid.org/0000-0002-2797-1443)
- Sonja W. Scholz (ORCID: https://orcid.org/0000-0002-6623-0429)
- Alexey Kozlenkov (ORCID: https://orcid.org/0000-0002-2569-0437)
- DM Adams
- Danielle M. Picarello (ORCID: https://orcid.org/0000-0001-5270-3259)
- Betul Comertpay
- Brian Fulton‐Howard
- Alison M. Goate
- Alan E. Renton
- Ruth Chia
- Edoardo Marcora
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- University Medical Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institute on Aging (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105172
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00