Brain cholesterol metabolism in Alzheimer's disease: Insights from ADNI and the UK BioBank
These findings implicate brain cholesterol metabolism in cognitive decline and dementia risk, with specific effects on AD pathophysiology. Brain cholesterol metabolism is implicated as a potential pathway for targeted preventative and therapeutic intervention strategies.
Authors
- Lisa Xiong
- Meghan J. Chenoweth (ORCID: https://orcid.org/0000-0002-8218-8240)
- Che‐Yuan Wu (ORCID: https://orcid.org/0000-0001-8548-1824)
- Daniel K Mori‐Fegan (ORCID: https://orcid.org/0000-0003-1290-7710)
- Yong‐Chuan Wong
- Si Won Ryoo
- Myuri Ruthirakuhan
- Sofia Perfetto
- Walter Swardfager
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105070
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00