Genetic variants in <i>MAPT</i> are associated with Alzheimer's disease blood biomarkers in South Asians from the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia
The analysis highlights a critical role of MAPT in tau pathology in South Asians. The observed association does not seem to be fully driven by known risk haplotypes. It also provides evidence to suggest modification by APOE-e4. Further investigation of MAPT haplotype structure in this population is warranted.
Authors
- X. Zhou
- Priya Moorjani (ORCID: https://orcid.org/0000-0002-0947-5673)
- Bharat Thyagarajan (ORCID: https://orcid.org/0000-0001-6968-6985)
- Masroor Anwar (ORCID: https://orcid.org/0000-0001-7529-7388)
- Peifeng Hu
- Jinkook Lee
- Gerald D. Schellenberg
- Yuk Yee Leung
- Li‐San Wang
- Hasan Abu‐Amara
- Sharmistha Dey
- Kumarasamy Thangaraj
- Zheng Li
- Sharon L R Kardia
- Aparajit Ballav Dey
- Jennifer A Smith
- Eileen M. Crimmins
- Wei Zhao
Institutions
- University of Southern California (US)
- University of Minnesota (US)
- University of California, Los Angeles (US)
- Centre for Cellular and Molecular Biology (IN)
- University of Michigan (US)
- All India Institute of Medical Sciences (IN)
- University of Pennsylvania (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100340
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00