Electrode Type and Long-Term Clinical Response to Responsive Neurostimulation: A Single-Center Cohort With 5-Year Follow-up

We report longitudinal clinical benefit to RNS in support of multicenter trial findings, expanding on findings that electrode type correlates with clinical response. One subdural electrode may be sufficient to realize benefit over depth electrodes alone. The five-year response to RNS was improved with at least 1 subdural electrode over depth electrodes alone, with further benefit in the rate of super-response when 2 subdural electrodes were implanted. When evaluating patients for RNS therapy, these data support the use of subdural over depth electrodes when appropriate.