The Impact of <i>PLCG2*M28L</i> and Diet on Neuro‐metabolic and Vascular Dysfunction in Novel Mouse Models of Late‐Onset Alzheimer's Disease
Data collected to date revealed that Plcg2 and HFD have a similar effect on the end biology of the brain. Moreover, this suggests Plcg2 is involved in an inflammatory process in a similar manner to HFD; however, Plcg2 in the presence of HFD showed to be responsive to the diet effect in a regulatory manner which reduced disease stage.
Authors
- Scott A. Persohn
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Kierra Eldridge
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Juan Antonio K. Chong Chie (ORCID: https://orcid.org/0000-0003-3111-2294)
- Adrian L Oblak
- Stacey J Sukoff Rizzo
- Bruce T. Lamb
- Gregory W Carter
Institutions
- University of Pittsburgh (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098702
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00