Understanding the role of Aβ and Tau in neuronal vulnerability in models of sporadic Alzheimer's disease
iPSC lines respond differently to Amyloid b (Ab) insult, and this inter-individual variation in vulnerability in cellular phenotypes such as neurite outgrowth correlates with clinical measures such as hippocampal volume. AB induces robust transcriptomic changes of i3 cortical neurons, including lipid metabolism and proteosomal perturbations and potential changes in gene expression due to AB insult in the sAD patients neurons is being further investigated.
Authors
- Nora Bengoa‐Vergniory (ORCID: https://orcid.org/0000-0002-3700-0464)
- Féodora L. Bertherat (ORCID: https://orcid.org/0000-0002-6717-6663)
- Sally A. Cowley (ORCID: https://orcid.org/0000-0003-0297-6675)
- Becky C. Carlyle (ORCID: https://orcid.org/0000-0003-1491-3217)
- Richard Wade‐Martins
Institutions
- University of Oxford (GB)
- Achucarro Basque Center for Neuroscience (ES)
- Wellcome Centre for Integrative Neuroimaging (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100973
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00