Exploring cell type‐specific hippocampal transcriptional signatures in amyloidosis mouse models
We found that fAD models had greater transcriptional alterations than the LOAD model, possibly due to the aggressive pathology caused by fAD mutations. Additionally, neurons were consistently affected across all models, highlighting their vulnerability to AD. Overall, the three models exhibited distinct transcriptional and biological signatures, suggesting each one of them is suited to address specific aspects of the AD landscape.
Authors
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Rodrigo Sebben Paes (ORCID: https://orcid.org/0000-0002-2330-4862)
- Gabriela Mantovani Baldasso
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- McGill University Health Centre (CA)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105268
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00