Inflammatory modulation and cellular stress response to lithium treatment in the hippocampus of Alzheimer's disease
Chronic lithium treatment effectively modulated neuroinflammation in Alzheimer's transgenic mice by reducing pro-inflammatory markers and reorganizing molecular networks associated with TLRs, particularly TLR4. These findings reinforce lithium's potential as a therapeutic modulator, though further investigations are needed for translation to human clinical studies.
Authors
- Luara Bela Rocha Gomes (ORCID: https://orcid.org/0009-0007-9667-4593)
- Carlos Wagner Leal Cordeiro Júnior (ORCID: https://orcid.org/0000-0002-4943-8949)
- Orestes Vicente Forlenza (ORCID: https://orcid.org/0000-0002-6962-5899)
- Vanessa V.J. De‐Paula
- CaíquePortugal de OliveiraCouto
Institutions
- Universidade de São Paulo (BR)
- Universidade Federal do Piauí (BR)
- Universidade Estadual do Piauí (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100586
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00