Sex differences in acute axon degeneration after traumatic brain injury in swine
These data identify sex differences in the extent of axonal pathologies in brain white matter acutely after TBI, which appears related to sex differences in axon diameter. Notably, these findings further shed light on insights that damaged and degenerating axons following TBI may provide a rich source of APP/Aβ as pathologic substrate contributing to the development of AD and its sex differences.
Authors
- H. Song
- Yue Qiu (ORCID: https://orcid.org/0000-0003-4714-9745)
- Jean‐Pierre Dolle
- D. Kacy Cullen
- William Stewart
- Douglas H Smith
Institutions
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103002
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00