Skin microbiome composition and function in the development of atopic diseases during infancy
Infant atopic phenotypes are associated with distinct, phenotype-specific features of the skin microbiome that emerge both before and after clinical disease onset. By resolving microbial differences within AD according to allergic co-occurrence, host genetics, and early-life timing, this study highlights the infant skin microbiome as a potential target for early risk stratification.
Authors
- Clay Deming (ORCID: https://orcid.org/0000-0002-7745-1518)
- Zeyang Shen (ORCID: https://orcid.org/0000-0003-3870-1390)
- J. Segre
- Heidi H. Kong (ORCID: https://orcid.org/0000-0003-4424-064X)
- Lindsay Chatman
- Karen Laky (ORCID: https://orcid.org/0000-0002-8197-3941)
- Jenny Min Li
- Katrina J. Allen (ORCID: https://orcid.org/0000-0002-1921-4493)
- Qiong Chen (ORCID: https://orcid.org/0000-0003-3354-4269)
- Richard R.S. Saffery
- Audrey Walsh
- Jana Eckert
- VITALITY team
- Pamela A Frischmeyer Guerrerio
- NISC Comparative Sequencing Program
- Kirsten P Perrett
Institutions
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Human Genome Research Institute (US)
- National Institute of Allergy and Infectious Diseases (US)
- Murdoch Children's Research Institute (AU)
- Washington State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-23
- DOI
- https://doi.org/10.64898/2025.12.22.696050
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Children’s Hospital of Wisconsin Research Institute
- Immune Tolerance Network
- Murdoch Children's Research Institute
- Australian Government
- State Government of Victoria
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases