Genetic Insights into Alzheimer's Disease from Cuban American Studies
This study replicated the associations of SORL1, CR1, ADAM17, RASGEF1C, SPI1, and ADAMTS1 with AD risk and protection are found in Cuban Americans. The large effect of the APOE4 aligns with its established role in AD pathogenesis across different populations. These results enhance our overall understanding of the genetic underpinnings of AD and support the advancement of targeted research and therapeutic interventions.
Authors
- Patrice Whitehead
- Michael Cuccaro
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Katrina Celis
- Concepcion Silva‐Vergara
- Jeffery M. M Vance
- Michael B. Prough
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Glenies S Valladares
- Sabrina Mas
- Katalina McInerney
- Vanessa C. Rodriguez
- Jose J. Sanchez
- Margaret Pericak‐Vance
- Larry D Adams
- Farid Rajabli
- Nicholas Gomez
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106251
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00