Mitochondrial DNA release via mPTP and BAX/BAK drives inflammatory injury in intestinal ischemia reperfusion
These findings identify mtDNA as a potential biomarker for IIR and highlight the MCU-mPTP-BAX/BAK axis as a therapeutic target.
Authors
- Ke Ding (ORCID: https://orcid.org/0000-0001-9016-812X)
- Yiguo Zhang (ORCID: https://orcid.org/0000-0003-3910-2779)
- R. Chen
- Tulanisa Kadier
- Yixin Jing
- Qingtao Meng
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12964-025-02603-3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00