Integrating metabolism into a computational model of brain health across the human lifespan

Having a comprehensive brain health model across the lifespan that includes metabolism would allow us to estimate the metabolic trajectory leading up to symptomatic appearance. We could then estimate the future trajectory of AD biomarkers based on a person's risk factor profile, thus providing a starting point for earlier AD diagnosis. Reference: Göbel, B., Langemann, D., Oltmanns, K. M., & Chung, M. (2010). Compact Energy Metabolism Model: Brain Controlled Energy Supply. Journal of Theoretical Biology, 264(4), 1214-1224. https://doi.org/10.1016/j.jtbi.2010.02.033.