SuperAging is associated with reduced age‐related cortical neuroinflammation in the absence of neuropathology
These preliminary findings suggest that the SuperAging phenotype may be associated with reduced cortical neuroinflammation at the molecular and cellular level. Further, we established a novel imaging spatial transcriptomic atlas of the aging human middle frontal gyrus across abnormal and supranormal trajectories of cognitive aging.
Authors
- G. R. Scott Budinger (ORCID: https://orcid.org/0000-0002-3114-5208)
- Rogan A. Grant (ORCID: https://orcid.org/0000-0003-0655-0882)
- Tamar Gefen (ORCID: https://orcid.org/0000-0002-2380-3100)
- Marek M. Mesulam
- Rachel Keszycki (ORCID: https://orcid.org/0000-0001-7686-2959)
- Karolina J. Senkow (ORCID: https://orcid.org/0000-0001-9942-3529)
- Antonia Zouridakis (ORCID: https://orcid.org/0000-0002-6404-3558)
- A. Misharin
- Allegra Kawles (ORCID: https://orcid.org/0000-0003-3153-5350)
- Grace Minogue (ORCID: https://orcid.org/0000-0002-1324-1351)
- M. Schleck (ORCID: https://orcid.org/0009-0003-2490-723X)
- Caroline M Nelson
- Molly A Mather
- Changiz Geula
- Rudolph J Castellani
- Alyssa Macomber
Institutions
- Northwestern University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102354
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00