Common Genetic Variants and Pathways Between COPD and AD: Insights from a GWAS of Over 300,000 Individuals in UK Biobank

The seven identified risk loci highlight the shared roles of potential pathogenic gene polymorphisms between COPD and AD. These novel candidate genes provide further evidence supporting the overlapping genetic susceptibility between the two diseases. Additionally, FUMA GWAS analysis of AD revealed a strong genetic correlation with COPD, with seven significant SNPs shared across the GWAS results of both conditions.