Allosteric Proteasome Activation Interactions Drive Tau Degradation Efficiency
The sensitivity of small hydrophobic amino acid leucine in the P5 position of NLSYYT significantly impacts the stability of the 20S gate. Remaining protein-protein interactions within a partially closed 20S gate clash with tau entry. By leveraging this information, proteasome activators designed for tau degradation strategies can be designed around controlling the rate of tau degradation.
Authors
- Bryan D. Ryder (ORCID: https://orcid.org/0000-0003-1393-0875)
- N. Yan (ORCID: https://orcid.org/0000-0003-4978-550X)
- Jason E. Gestwicki (ORCID: https://orcid.org/0000-0002-6125-3154)
- ALBORADA Drug Discovery Team
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102534
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00