The Potential of Using ADRD‐related Biomarkers to Predict and Diagnose Perioperative Neurocognitive Disorders in Elderly Patients Undergoing Surgery
Surgery may enhance Alzheimer's and related diseases biomarkers in both NCD and non-NCD groups. The Aβ42/p-Tau 181 ratio after surgery was significant in non-NCD cases. NCD cases showed the same trend and an increase in sample size will likely show the same finding. Neuronal injury observed in NCD patients was confirmed by the elevation of UHCL-1.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- William Macaulay (ORCID: https://orcid.org/0000-0003-2684-0676)
- Vinay K. Aggarwal (ORCID: https://orcid.org/0000-0001-9349-6487)
- RS Osorio
- Lisa Doan (ORCID: https://orcid.org/0000-0002-7833-1753)
- Alok Vedvyas
- Elaine Zhu (ORCID: https://orcid.org/0000-0003-2690-9100)
- Karyn Marsh (ORCID: https://orcid.org/0009-0003-9057-1551)
- Braden V Saba (ORCID: https://orcid.org/0000-0003-2092-4852)
- David Furgiuele (ORCID: https://orcid.org/0000-0003-4121-1843)
- Joshua C. Rozell (ORCID: https://orcid.org/0000-0003-0556-0077)
- Evan T. Schulze
- Ekow Commeh (ORCID: https://orcid.org/0000-0001-9070-9061)
- Mika M. Rockholt (ORCID: https://orcid.org/0000-0002-8899-8551)
- Ludovic Debure
- Wajiha Ahmed (ORCID: https://orcid.org/0009-0007-8121-0307)
- Christina Bi (ORCID: https://orcid.org/0009-0003-5717-0385)
- Mobeena Ghuman
- R M Daza Pérez
- Rachel R. Wu
- Romario B. Denoon
- Allal Boutajangout
- Daniel Waren
- Wonyoung Park
- Gabrielle Bruno
- Jing Wang
- Ran Schwarzkopf
- Hamleini Martinez
- Courtney O'Brien
- Thomas Wisniewski
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Allen Institute for Brain Science (US)
- NYU Langone Health (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Cognitive Research (United States) (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101699
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00