The interplay between synaptic integrity and age at menopause on Alzheimer's disease risk in women
In the setting of reduced synaptic integrity, women with earlier menopause show greater tau and steeper cognitive decline. These findings suggest that midlife endocrine processes or their sequelae modify the links between late-life synaptic integrity and brain health outcomes. Interventions targeting both factors could promote resilience to AD in women.
Authors
- Liisa A.M. Galea (ORCID: https://orcid.org/0000-0003-2874-9972)
- Madeline Wood Alexander (ORCID: https://orcid.org/0000-0003-4598-0201)
- Jennifer S Rabin
- Rowan Saloner
- William G Honer
- Kaitlin B Casaletto
- David A. A. Bennett
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of California, San Francisco (US)
- University of Toronto (CA)
- University Memory and Aging Center (US)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100373
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00