A novel potent autophagy inhibitor HM-013 limits production of infectious dengue virus particles

HM-013 is a promising autophagy inhibitor with potent anti-DENV activity and low cytotoxicity, supporting its further development as a potential dengue therapeutic.

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Publication Details

Journal
Virology Journal
Published
2025-12-24
DOI
https://doi.org/10.1186/s12985-025-03053-6
Primary Topic
Mosquito-borne diseases and control
Type
article
Field-Weighted Citation Impact
0.00
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A novel potent autophagy inhibitor HM-013 limits production of infectious dengue virus particles

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A novel potent autophagy inhibitor HM-013 limits production of infectious dengue virus particles

Jitra Limthongkul, Phongthon Kanjanasirirat, Supawan Jamnongsong, Sineenart Attanonchai, Tanawadee Khumpanied, Suparerk Borwornpinyo, Alisa Tubsuwan, Marisa Ponpuak, Poonsakdi Ploypradith, Orakot Simanurak, Tanpitcha Yodweerapong, Sukathida Ubol, Somponnat Sampattavanich
article en

Abstract

HM-013 is a promising autophagy inhibitor with potent anti-DENV activity and low cytotoxicity, supporting its further development as a potential dengue therapeutic.

Virology JournalVol. 23(1)
Siriraj Hospital (TH), Mahidol University (TH), Chulabhorn Research Institute (TH)
Good health and well-being
Openalex Percentile: Top 27%
Mosquito-borne diseases and control
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