Determining the functional relevance of <i>PSEN2</i> 3′UTR isoforms in Alzheimer's disease
Collectively, our data establish 1) an in vitro model to test PSEN2 3'UTR isoforms, 2) miRNA expression differences in human AD synaptosome and homogenate fractions, and 3) decreased PSEN2 transcript signal in human AD frontal cortex tissue. Elucidating the functional significance of PSEN2 3'UTR isoform regulation will further our understanding of AD.
Authors
- Evangelos Nizamis
- Eli J. Kaufman (ORCID: https://orcid.org/0000-0001-8553-210X)
- Julianna N. Brutman (ORCID: https://orcid.org/0000-0001-9230-3647)
- Tina Busald
- Samuel N. Smukowski
- Paul N. Valdmanis (ORCID: https://orcid.org/0000-0001-8840-6969)
- Marissa J de Leon
Institutions
- University of Washington (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105273
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00