Efficacy and safety of pharmacological and non-pharmacological interventions for antipsychotic-induced weight gain in individuals with schizophrenia: A systematic review and network meta-analysis of 55 clinical trials
We found that Semaglutide has the highest probability of being the most effective therapy in the reduction of weight gain and BMI. Liraglutide was associated with mild adverse effects. Additional trials focusing on non-pharmacological approaches are essential.
Authors
- Michel Sabe
- Mohamed Ahmed (ORCID: https://orcid.org/0000-0003-2880-0002)
- Mohamed Ezzat M. Mansour (ORCID: https://orcid.org/0009-0002-2195-2353)
- Mohamed M. M. Mustafa (ORCID: https://orcid.org/0009-0002-8987-1875)
- Khalid Radwan Alsaadany
- Ahmad Beddor
- Omar Kassar (ORCID: https://orcid.org/0009-0009-9203-5107)
- Fares Abdelsalam (ORCID: https://orcid.org/0000-0001-6879-1652)
- A.S. Elgahamy (ORCID: https://orcid.org/0000-0001-9685-8869)
- Mohamed Mohsen Helal
- Ahmed Ezzat Elmetwalli
Institutions
- University of Geneva (CH)
- Suez University (EG)
- Misr University for Science and Technology (EG)
- Mansoura University (EG)
- Al-Azhar University (EG)
- Zagazig University (EG)
- University Hospital of Geneva (CH)
- Egyptian Russian University (EG)
- Alexandria University (EG)
- Yarmouk University (JO)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1177/02698811251399544
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00